Endemic PF, also known as Fogo Selvagem (FS) shares with the sporadic nonendemic form of PF clinical features and pathogenic IgG4 autoantibodies (Rock et al., 1989) directed against the ectodomains of desmoglein 1 (Dsg1) (Amagai and Stanley, 2012). The gene discussed is DSG1; the disease is pemphigus foliaceus.