The potential cross-reactivity of some sand fly salivary gland proteins (LJM 17 and 11 in the NW and PpSP32 in the OW) with Dsg1, the autoantigen of endemic pemphigus foliaceus, indicates the need for a careful choice when selecting such proteins as candidates for anti-Leishmania vaccines. Here, DSG1 is linked to pemphigus foliaceus.