BMAL1 and serum lipopolysaccharide activity: During the two days from the onset of endotoxemia at the late resting phase to death, the circadian expression rhythm of the Bmal1 gene becomes arrhythmic and remains at a high level in the lung, while that of the Rev-erbα gene shows a distorted but rhythmic pattern compared to healthy lungs (Haspel et al., 2014).