CD4 and cancer: The depletion of CD8+/CD4+ T cells and NK cells is reported to promote the occurrences of EBV-driven cancers (Murer et al., 2019; Münz, 2021), and extra evidence has also been claimed that the coinfection of EBV and some pathogen could have induced the EBV reactivation and impaired the EBV-targeted immune cell response.