Edsfeldt et al. [30] investigated the association between increased Gal-3 levels and stroke incidence following carotid endarterectomy (CEA) and found that even after adjusting for a number of important covariates (including demographic data, statin use, and smoking status), high Gal-3 levels maintained a significant association with stroke occurrence, with a hazard ratio (HR) of 4 (95% CI 1.6 to 10.4, p = 0.004). This evidence concerns the gene LGALS3 and Stroke.