Various molecular abnormalities like <i>TET2, SRSF2, ASXL1,</i> and <i>RAS</i> are reported in the pathogenesis of CMML, but no such mutations have been described to explain the strong association of autoimmune diseases and severe inflammatory phenotype seen in CMML. The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.