The level of thrombin (the ligand of PARs) has been found to be elevated and the expression of PAR-1 and PAR-4 on the activated MG surface was highly consistent with the activation of MG (Wan et al., 2016) also reached the same conclusion, that PAR-1 was predominantly involved in ICH induced brain injury and regulate microglia polarization. The gene discussed is F2R; the disease is brain injury.