Aggregation is also a feature of HSPB5 mutants linked to myopathies, cardiomyopathies or more severe multisystem disorders (Vicart et al., 1998; Inagaki et al., 2006; Reilich et al., 2010; Brodehl et al., 2017; Fichna et al., 2017). The gene discussed is CRYAB; the disease is cardiomyopathy.