CRYAB and Cognitive impairment: These include the HSPB5 A172Pfs*14, linked to a multisystem syndrome, consisting of congenital cataract, hypotonia and a slight delay in motor skills acquisition without cognitive impairments, and HSPB5 X176Wext*19, linked to cataracts and DCM (Marcos et al., 2020; Yinhui Yu et al., 2021).