Moreover, the HSPB7 NTD mediates the HSPB7 anti-aggregating and pro-degradative activities against misfolded proteins involved in neurodegenerative diseases (NDs) via autophagy (Vos et al., 2010; Minoia et al., 2014; Wu et al., 2019). The gene discussed is HSPB7; the disease is neurodegenerative disease.