HR-deficiency is a molecular variation of genome instability, which is defined as carriers of BRCA1/2 mutations or tumor genomic instability (HRD score ≥42) (Telli et al., 2016; Sharma et al., 2018; Liao et al., 2021). Here, BRCA1 is linked to hyperinsulinemic hypoglycemia, familial, 4.