Ribosomal proteins other than Rpl5 also affect proper eye as well as brain development as Pescadillo homologue 1 (Pes1) and Peter Pan (Ppan) lead to malformed eyes, including coloboma, as well as microcephaly in developing Xenopus laevis (Gessert et al., 2007; Bugner et al., 2011). This evidence concerns the gene RPL5 and microcephaly.