The use of 3-D organotypic cultures allowed modeling of Flex-Het tissue level effects, which revealed drug-induced formation of more-orderly tissue structures including mucin-producing glands in ovarian cancer cultures and tubules in kidney cancer cultures in association with upregulation of Mucin-1 and E-Cadherin, respectively (Guruswamy et al., 2001; Liu et al., 2009). The gene discussed is CDH1; the disease is kidney cancer.