While SHetA2 caused only moderate and no cleavage of caspase eight in lung and ovarian cancer cells, respectively, it sensitized these cancer cells to caspase eight cleavage and apoptosis by death receptor ligands, tumor necrosis factor α (TNFα) and TNF-related apoptosis inducing ligand (TRAIL) (Lin et al., 2008a; Lin et al., 2008b; Moxley et al., 2009; Chengedza and Benbrook, 2010). The gene discussed is TNF; the disease is cancer.