It has been demonstrated that the TLR2 pathway regulates Ca2+ mobilization through the cell; TLR2 agonist, Pam3Cys, stimulates Ca2+ influx in neutrophils (Conejeros et al., 2015), human mast cells (Yu et al., 2014), and airway epithelial cells via TLR2-dependent signaling and modulates proinflammatory response to bacterial infection (Chun and Prince, 2006). The gene discussed is TLR2; the disease is bacterial infectious disease.