In addition, aging-related increment in terminal keratinocyte differentiation markers (filaggrin and loricrin) and decrement in epidermal hyperplasia markers (Ki16 and Ki67) were also observed in AD (Zhou, et al., 2019), which might be attributable to attenuation in the Th2/Th22 cytokine axes (Boniface, et al., 2005); moreover, it reveals a critical role for crosstalk between immune cell senescence and stromal cell-mediated immunity impairment in severity of geriatric AD. Here, LORICRIN is linked to Alzheimer disease.