Moreover, in spontaneous lung carcinomas (R26-GB2) and oncogene-driven breast cancers, GSDMB2 was mostly cytoplasmic but nuclear localization was noted in some tumor areas (usually more intense in GB2+/+ than GB2+/-mice, indicating enhanced protein accumulation with increased GSDMB2 gene dosage). This evidence concerns the gene GABBR2 and breast carcinoma.