However, two difficulties have prevented so far determining the precise GSDMB in vivo cancer functions: a) the lack of preclinical murine models, since mice and rat lack GSDMB orthologue; b) The existence of four GSDMB translated isoforms that can play different roles in cancer (Carl-McGrath et al., 2008; Sun et al., 2008; Hergueta-Redondo et al., 2014; Lutkowska et al., 2017) and inflammatory diseases (Morrison et al., 2013; Das et al., 2016; Panganiban et al., 2018). The gene discussed is GSDMB; the disease is cancer.