Indeed, nuclear GSDMB provokes the transcriptional induction of the same set of genes (TGF-β1 and 5-lipoxygenase) in human bronchial epithelial cells and the lungs of the hGSDMBZp3−Cre KI model (ubiquitously expressing the longest isoform, GSDMB3) after asthma challenge (Das et al., 2016). This evidence concerns the gene TGFB1 and asthma.