Strikingly, the asthmatic phenotype of the hGSDMBZp3−Cre model was mechanistically mediated by the transcriptional regulation of certain genes (Das et al., 2016), not via a cell death mechanism, while in human lung cells asthma has been linked to the pyroptotic effect of specific GSDMB isoforms (Morrison et al., 2013; Das et al., 2016; Panganiban et al., 2018). Here, GSDMB is linked to asthma.