Additionally, Gsdme KO mice exhibit no clear effects on carcinogenesis, tumor differentiation and progression in two experimental models of intestinal cancer (the chemical induction by azoxymethane -AOM- or crossing with the Apc1638N/+ intestinal cancer mouse strain) (Croes et al., 2019), but these animals have significantly reduced colitis severity and tumor formation when AOM was combined with Dextran Sodium Sulphate (Tan et al., 2020). Here, GSDME is linked to infectious otitis media.