In the ApoE−/- mouse AS model induced by the Western diet, anti-HMGB1 antibodies were more than six times higher than regular diet ApoE−/- mice and ApoE+/+ mice, indicating that HMGB1 autoimmunity is involved in the progression of AS (Pan et al., 2016). The gene discussed is HMGB1; the disease is Autoimmunity.