TNFSF10 and neoplasm: To study the impact of pHe on TRAIL-induced signaling in PDAC cells, we established Colo357 and Panc1 cell lines adapted for a longer period of time to either of the three pHe conditions: pHe 6.5 (simulating pHe in the tumor microenvironment), pHe 7.6 (corresponding to the luminal pHe in the exocrine pancreas), or pHe 7.4 (control).