Acidic pHe has been shown to be able to potentiate TRAIL-induced cell death in some cancer types such as prostate carcinoma (Lee et al., 2004), colorectal carcinoma (Lee et al., 2004), gastric carcinoma (Hong and Han 2018), colon carcinoma (Meurette et al., 2007), hepatocarcinoma (Meurette et al., 2007), and lung cancer (Valiahdi et al., 2013). The gene discussed is TNFSF10; the disease is cancer.