The TRAIL-induced apoptotic pathway is frequently inhibited in cancer cells leading to the de-masking of the potential of TRAIL death receptors to induce several pro-inflammatory signaling pathways, which may ultimately result in tumor progression (von Karstedt et al., 2017; Trauzold et al., 2001; Trauzold et al., 2006; Hoogwater et al., 2010; Azijli et al., 2010). This evidence concerns the gene TNFSF10 and cancer.