Beyond that, we also found that autophagy played a crucial role in IR-mediated chemo-resistance in HCC by regulating the endoplasmic reticulum stress (Li et al., 2018), and many differentially expressed miRNAs (miR-134-5p, miR-5195-3p) and predicted target genes (YAP1, SOX9, TPM4) might be related to IR-mediated chemoresistance in HCC (Li et al., 2020). This evidence concerns the gene YAP1 and hepatocellular carcinoma.