RHOA and urinary bladder cancer: Shin et al. (Shin et al., 2017) found that HSPA6 induces phosphorylation of MAPK and AKT signals in bladder cancer cells and inhibits transcription factor related MMP-9 regulation to act on garlic extract, thus enhancing its mediated inhibition of bladder cancer cell proliferation, migration, and invasion; Meanwhile, Wang et al. (Wang et al., 2020b) showed that the expression of ARHGEF10L can stimulate gastric cancer by promoting RhoA-Rock1-phosphorylation-ERM signal transduction, inducing epithelial-mesenchymal cell transformation (EMT) and increasing HSPA6 expression.