To ensure the feasibility and stability of the clinical prognostic value of these 67 genes, LASSO analysis was conducted, and we obtained 16 energy–metabolism-correlated genes associated with the prognosis of patients with BLCA, including FBP1, AOC2, SLC16A8, IDUA, CYP2C8, GPC2, HS3ST1, UGT2B7, GSTM1, CSPG4, ACY3, SLC16A3, TPST1, CES1, HSPG2, and CYP1B1 (Figures 5A,B). The gene discussed is HSPG2; the disease is bladder transitional cell carcinoma.