PPARG and bladder transitional cell carcinoma: A recent study found that mutations in peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor connecting glucose and fatty metabolism, led to immune suppression, such as inhibiting the infiltration of CD8+ T cells in the tumor microenvironment, which may play an important role in checkpoint inhibition in BLCA (Korpal et al., 2017).