ACY3 and bladder transitional cell carcinoma: To ensure the feasibility and stability of the clinical prognostic value of these 67 genes, LASSO analysis was conducted, and we obtained 16 energy–metabolism-correlated genes associated with the prognosis of patients with BLCA, including FBP1, AOC2, SLC16A8, IDUA, CYP2C8, GPC2, HS3ST1, UGT2B7, GSTM1, CSPG4, ACY3, SLC16A3, TPST1, CES1, HSPG2, and CYP1B1 (Figures 5A,B).