The hypoxia-activated Seven in absentia homolog 2 (SIAH2)-nuclear factor erythroid-derived 2-related factor 1 (NRF1) signal axis suppresses mitochondrial function and induces immune response of protumor in macrophages, and regulation of NRF1 in macrophages could inhibit polarization of TAMs and restrain tumor maintenance in breast cancer (46). Here, NRF1 is linked to neoplasm.