In terms of the top 15 genes of mutation, TP53, TTN, MUC16, CSMD3, RYR2, LRP1B, ZFHX4, USH2A, KRAS, SPTA1, XIRP2, and FLG were the same in the high- and low-risk groups, which showed the importance of the mutation of 12 genes in cancer progression (Figures 6B, E). Here, RYR2 is linked to cancer.