Further mechanism study let us know that SNRPA1 impacted the tumorigenesis of ccRCC through RNA splicing, DNA replication, and activation of ATPase and methyltransferase, as well as the activation of E2F targets and MYC targets, p53 signaling, and epithelial–mesenchymal transition (EMT) differentiation. Here, DNAH8 is linked to nonpapillary renal cell carcinoma.