STAT3 and neoplasm: Furthermore, we calculated the activation status of HALLMARKER tumor signatures between SNRPA1 high and low groups, revealing that high-level SNRPA1 correlated with the activation of G2M checkpoint, MYC targets, E2F targets, interferon gamma response, IL6/JAK/STAT3 signaling, and interferon alpha response pathways, while low SNRPA1 correlated with the activation of androgen response, protein secretion, fatty acid metabolism, and hypoxia pathways (Figure 4C).