For second/third-line treatment in HER2-mutated NSCLC, single ICIs are usually used; a retrospective study observed an ORR of 29% and a median PFS of 3.6 months in 14 patients (12), and another real-world study showed an ORR of 27.3% and a median OS of 20.4 months in 23 patients (13). This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.