Although PRRX1 was found to mediate carcinoma cell invasion and metastasis by inducing the EMT (37, 45, 46), other studies found that the loss of PRRX1 results in the reversion of the EMT and the induction of the MET, favoring metastatic colonization (32, 47, 48). The gene discussed is PRRX1; the disease is carcinoma.