Both univariate (hazard ratio [HR]: 2.324, 95% confidence interval [CI]: 1.514–3.566, p <0.001) and multivariate (HR: 2.571 95% CI: 1.465–4.513, p <0.001) analyses of 75 patients in the TCGA-UVM cohort with complete information on age, gender, stage, T classification, tumor diameter, tumor thickness, and extra scleral extension showed that high PRRX1 expression was a powerful and independent prognostic predictor of reduced OS (Figure 6A). Here, PRRX1 is linked to neoplasm.