Given that the tumor-infiltrating NK cells produce large amounts of IFNγ which is one of the key cytokines to inhibit tumor growth and that intILC1s and ILC1s mainly produce the pro-angiogenic molecule PDGF-AB and pro-tumorigenic cytokine TNFα (58), TGF-β signaling is considered as prone to favor tumor immune evasion. The gene discussed is TGFB1; the disease is neoplasm.