Intervention strategies, such as anti-programmed cell death (PD)-1/PD-L1 mAb, blocking cytotoxic T lymphocyte antigen (CTLA)-4, and blocking 2B4, have improved survival in experimental models of sepsis and recent clinical trials through improved T cell-induced immunosuppression (46, 55–58). This evidence concerns the gene PDCD1 and Sepsis.