Establishment of sepsis models such as the “memory mouse” (57, 95), “two- or three-hit mouse” (70, 118), and “gene recombination mouse” models (78, 79, 94) have begun to shed light on additional heterogeneous immune characteristics in sepsis, including the presence of IL-10+ regulatory B cells (Bregs) and lipopolysaccharide-responsive beige-like anchor protein (LRBA)-deficient patients (97, 126, 127). The gene discussed is IL10; the disease is Sepsis.