To investigate whether (CD68-CSF1R-IL1BhiCD14+)classical monocytes were associated with the disease progression, we examined two SM patients who had PBMC samples collected at two different time-points, including patient #1 (a fatal patient): COV012 (time-point 1) and COV077 (time-point 2); and patient #2 (an SD patient at the recovery stage): COV029 (time-point 1) and COV126 (time-point 2). The gene discussed is CD68; the disease is systemic mastocytosis.