Notably, (CD4loCSF1R-CD33-CD14+), (CD33-HLA-DMA-CD14+), (CSF1R+CD86-CD14+) and (CXCL8+CSF1R-IL1B-CD14+) classical monocytes decreased significantly in the SM patients (Table 1), suggesting that these cell subsets may negatively associated with the disease symptoms. This evidence concerns the gene CD14 and systemic mastocytosis.