Although the effect of ADAM10 in SSc fibrosis has not been studied, the apparent pro-fibrotic effect of ADAM10 in other fibrotic conditions might imply that the anti-fibrotic effect of the ADAM10-mediated GPNMB shedding pathway plays a minor role in the overall pro-fibrotic phenotype observed in SSc due to the suppressive effect of TGFβ upon the sGPNMB-mediated anti-fibrotic effect. The gene discussed is TGFB1; the disease is systemic sclerosis.