KLF5 and asthma: The expression of HDAC4 was upregulated in lung tissues of asthmatic mice, and it could deacetylate Kruppel-like factor 5 (KLF5) to upregulate Slug and CXC chemokine ligand-12 (CXCL12), thus triggering airway remodeling and promoting progression of asthma (26).