At the same time, energy expenditure pathways such as lipogenesis and OXPHOS in adipose tissue are inhibited to save energy substrates for FA β-oxidation gene-enriched PCa cells, with an up-regulated level of the rate-limiting enzyme of the transport of long-chain FAs for β-oxidation, CPT1A, thus promoting EMT and cancer aggressiveness (76). Here, CPT1A is linked to posterior cortical atrophy.