Upon RNA viruses (such as VSV and SeV) and DNA viruses (e.g., HSV-1, vaccinia virus) infection, lncRNA-GM is downregulated in expression through a not-yet understood mechanism and thus frees GSTM1, which in turn, mediates the glutathionylation of TBK1 at the Cys637 site to reduce TBK1 kinase activity (72). Here, TBK1 is linked to infection.