This imbalance in the ratio of VWF level to ADAMTS13 increases the hypercoagulable state of COVID-19 patients and thereby risk of micro-thrombosis.45Thus, this cascade of events cause endothelium to adopt a procoagulant phenotype, which is then supportive of platelet and leukocyte recruitment and marks the initiation of CIC.46, 47. Here, VWF is linked to COVID-19.