Also, TLR-7 and TLR-8 recognizes the multiple single-stranded RNA fragments of SARS-CoV-2, thus contributing to innate immune hyper activation and causing a cytokine storm.38Thus, upon infection, the vascular endothelium, which is a guardian of vascular integrity, gets hijacked by the virus and then exposed to the milieu of proinflammatory cytokines elicited by the innate immunity.39All the studies conducted have hypothesized that the entry of the virus via endothelial-expressed ACE-2 paves the way by which the virus can enter and infect other tissues. This evidence concerns the gene TLR8 and infection.