IL-6, a crucial cytokine that is markedly increased in severe COVID-19, is an activator of coagulation that induces TF expression along with increased production of fibrinogen and platelets.48, 49, 50Increased Angiotensin II (ATII) expression, along with proinflammatory cytokines and antiphospholipid antibodies are responsible for TF activation and overexpression in the infected patients. The gene discussed is IL6; the disease is COVID-19.