Gaggiano et al. found that patients with juvenile idiopathic arthritis (JIA) related uveitis received a single conventional disease-modifying anti-rheumatic drugs (cDMARDs) does not achieve a good clinical response, especially concurrent UME, which may require a combination of biologic agents, such as interleukin-6 inhibitors, to achieve better therapeutic effect (14). The gene discussed is IL6; the disease is juvenile idiopathic arthritis.