FAS and 22q11.2 deletion syndrome: Later work from the same laboratory highlighted both the relative specificity and insensitivity of the cardinal facial dysmorphology of FAS as a marker of PAE.16,17 Whereas alcohol exposure in mice on gestational day 7 (corresponding to gastrulation) reproduced the cardinal facial dysmorphology of FAS, exposure on gestational day 8.5 (corresponding to neurulation) produced different facial anomalies more characteristic of DiGeorge syndrome or retinoic acid embryopathy.