Moncada-Pazos et al. found that ADAMTS12 is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer (7).The expression of ADAMTS12 in colorectal cancer-associated TME prevents cancer development and is a good prognostic indicator of colorectal cancer (14). The gene discussed is ADAMTS12; the disease is malignant colon neoplasm.