We further revealed that ADAMTS12 expression was positively correlated with immune checkpoint proteins (such as PDCD1, CD274, LAG3, and CTLA4), immunosuppressive genes (Supplementary Figure 4A), chemokines (Supplementary Figure 4B), and chemokine receptors (Supplementary Figure 4C) in most tumor types. The gene discussed is CTLA4; the disease is neoplasm.