ESR1 and cancer: There were several clinicopathological and treatment factors associated with breast cancer survival, including age, family history of cancer, TNM stage, histological type, tumor grade, Ki67, LVI, ER, PR, HER2 status, and receiving of adjuvant therapy (such as endocrine therapy, anti-HER2 therapy, and chemotherapy treatment) (P < 0.05) (Table 3).