TOP2A and acute myeloid leukemia: The Top2 poison doxorubicin and its isomer epirubicin from the anthracycline family are first-line antineoplastic agents used against many different types of solid tumors, leukemias, and lymphomas (26, 27), with main side effects including cardiotoxicity and t-AML (treatment-related acute myelogenous leukemia) (28–30).