CDK1 and adenocarcinoma: In comparison to the untreated control, the phosphorylation of Cdk1 on tyrosine 15 was increased after cisplatin, WN170 or WN197 treatments in the three adenocarcinoma cell lines, while it decreased after treatments with doxorubicin or nocodazole in HeLa and HT-29 and was slightly identical in MDA-MB-231 treated with doxorubicin.