CAFs, indeed, can enhance the invasive properties of cancer cells releasing several tumor-promoting growth factors and chemokines (for example, TGF-β, HGF, FGF1, and FGF2) and also molecules (like VEGF) that strongly induce angiogenesis, further supporting proliferative, migratory, and invasive abilities of cancer cells (29, 33, 35, 39–41). This evidence concerns the gene TGFB1 and neoplasm.