Using two different cell lines and a xenograft mouse model of CRC, it was shown that 2-Imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA), a benzopyran derivative, downregulates SLC7A11 levels leading to increased ROS and ferroptosis in CRC cells. The gene discussed is SLC7A11; the disease is colorectal carcinoma.