In recent years, ferroptosis has been associated with many pathologies including cancer, neurological diseases, ischemia etc. SLC7A11 overexpression confers resistance to ferroptosis in cancer cells by importing cystine for the synthesis of GSH and by relieving lipid ROS stress by activation of glutathione peroxidase 4 (GPX4) (22). The gene discussed is GPX4; the disease is nervous system disorder.