AKR1B10 and cancer: Serum levels of AKR1B10 were measured in subjects enrolled and, as noted in Figure 2A, were significantly elevated in patients with localized (6.72 ± 0.92 ng/ml) or metastatic (7.79 ± 1.13 ng/ml) disease as opposed to the cohort of cancer-free healthy women who had a mean serum value of 1.69 ± 0.17 ng/ml.