ALDH1A1 and thyroid tumor: Indeed, our Gene Ontology (GO) enrichment analysis revealed a close relationship between ALDH1A1/A3/B1 and ethanol oxidation (GO:0006069), as well as retinol metabolic process (GO:0042572), which are known to be important in detoxification (8), tumorigenesis (25), and thyroid tumor progression (Supplementary Material) (26).