IFIT3 and lung cancer: In addition, to explore the mechanism of COL8A1 upregulated IFIT1 and IFIT3-medicated EGFR activation, we overexpressed COL8A1 in lung cancer cells H1299 and H1975, and found that IFIT1, IFIT3 and pEGFR were upregulated by COL8A1 overexpression, whereas after co-transfected with COL8A1-overexpressing vectors and siIFIT1/siIFIT3, the expression of IFIT1, IFIT3 and pEGFR were suppressed, which indicated that COL8A1 promoted EGFR activation through upregulating IFIT1 and IFIT3 in lung cancer cells (Supplementary Figure 2).