Furthermore, our results show that knockdown of IFIT1 or IFIT3 can rescue the effects of COL8A1 on cell proliferation, migration, and apoptosis in NSCLC cell lines, indicating that COL8A1 contributes to NSCLC proliferation and invasion partly through regulating IFIT1 and IFIT3 expression, in turn, activation of EGFR. Here, COL8A1 is linked to non-small cell lung carcinoma.