PECAM1 and neoplasm: By evaluating the platelet endothelial cell adhesion molecule (PECAM-1), mainly found on the endothelial cells, they showed that the nanoparticle–hydrogel composite of docetaxel and LL37 dramatically inhibited angiogenesis in the tumor of the mouse model compared to the free combination of docetaxel and LL37 and pure docetaxel (microvessel density (MVD) was 19.67 ± 3.98 for the nanoparticle–hydrogel composite of docetaxel and LL37, 33.00 ± 7.40 for the free combination of docetaxel and LL37, and 65.50 ± 7.37 for pure docetaxel) (126).