For example, coupling CD20 with CD137 and CD3ζ can cause prolonged tumor regression for advanced diffuse large B cell lymphomas (39); autologous or donor-derived T cells expressing a CAR that targets CD19 and harbors CD137 and the CD3ζ moiety can cause regression of extramedullary B-cell lineage acute lymphocytic leukemia (37). This evidence concerns the gene TNFRSF9 and acute lymphoblastic leukemia.