established a radiation-resistant cell line CNE2-RR from fractionated radiotherapy irradiated nasopharyngeal carcinoma CNE2 cell line, and proteomic analysis identified 34 cases of differential proteins; after validated by 90 clinical tissue specimens of nasopharyngeal carcinoma, they identified that 14-3-3σ and maspin were significantly downregulated, conversely, GRP78 and Mn-SOD were significantly upregulated; cellular studies confirmed that upregulation of 14-3-3σ could effectively improve the radiation sensitivity of CNE2-RR cell lines (46). The gene discussed is HSPA5; the disease is nasopharyngeal carcinoma.