In contrast, other studies also found that higher KRT13 levels in colorectal cancer, gastric cancer, and tongue squamous cell carcinoma may promote the development of these cancers (41), and KRT13 showed the activity to promote metastasis of breast cancer by altering the nuclear translocation of plakoglobin and modulating downstream c-Myc-dependent signaling (42). This evidence concerns the gene KRT13 and tongue squamous cell carcinoma.