In contrast, other studies also found that higher KRT13 levels in colorectal cancer, gastric cancer, and tongue squamous cell carcinoma may promote the development of these cancers (41), and KRT13 showed the activity to promote metastasis of breast cancer by altering the nuclear translocation of plakoglobin and modulating downstream c-Myc-dependent signaling (42). Here, MYC is linked to tongue squamous cell carcinoma.