Besides the identification of Ku80 and TP53 as potential negative prognostic indicator in HNSCC, Eschrich et al., using the Radiosensitivity Index (RSI) in a retrospective study of HNSCC treated with radiochemotherapy identified a radiosensitive cohort of patients that saw improved locoregional control (21). The gene discussed is XRCC5; the disease is head and neck squamous cell carcinoma.