BRCA1 and colorectal carcinoma: Out of three recent meta-analyses, one of them found an increased risk of colorectal cancer associated with BRCA1 variants (odds ratio = 1.49, 95% CI = 1.19 to 1.85, P < 0.001) (8), while the other two did not identify any increase in CRC risk among patients carrying a BRCA1 variant (7, 9).