ERBB2 and breast carcinoma: Modern systemic therapies, including endocrine therapy for HR-positive disease, anti-HER2 therapy for HER2-positive disease, chemotherapy based on anthracycline and taxane, bone-stabilizing agents, poly (ADP-ribose) polymerase inhibitors for BRCA mutation carriers, and immunotherapy, have been demonstrated to significantly improve the survival outcomes of breast cancer patients (3).