In addition, stereotactic transplantation of ADSCs reduces the expression of tissue edema-related AQP4, which is attributed to the inhibition of upstream p28/mitogen activated protein kinase (MAPK) and JUN N-terminal kinase (JNK) signaling in astrocytes, thus maintaining the integrity of blood-brain barrier and the functional homeostasis of the brain after intracerebral hemorrhage 187. The gene discussed is MAPK8; the disease is intracerebral hemorrhage.