Considering that after co-culturing with adipocytes, the expression and secretion of CXCLs in breast cancer cells increased, and since studies have shown that LIF can induce the expression of CXCL8 to promote the proliferation of pancreatic cancer cells 30, we speculate that the expression of CXCLs may be regulated by the LIF/Stat3 signaling pathway in breast cancer cells. The gene discussed is STAT3; the disease is breast carcinoma.